Acquired von Willebrand factor deficiency caused by LVAD is ADAMTS-13 and platelet dependent.
Identifieur interne : 001388 ( Main/Exploration ); précédent : 001387; suivant : 001389Acquired von Willebrand factor deficiency caused by LVAD is ADAMTS-13 and platelet dependent.
Auteurs : Petra Jilma-Stohlawetz [Autriche] ; Peter Quehenberger [Autriche] ; Heinrich Schima [Autriche] ; Martin Stoiber [Autriche] ; Paul Knöbl [Autriche] ; Barbara Steinlechner [Autriche] ; Alessia Felli [Autriche] ; Bernd Jilma [Autriche]Source :
- Thrombosis research [ 1879-2472 ] ; 2016.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Dispositifs d'assistance circulatoire (effets indésirables), Facteur de von Willebrand (métabolisme), Femelle, Humains, Jeune adulte, Maladies de von Willebrand (métabolisme), Maladies de von Willebrand (étiologie), Mâle, Plaquettes (métabolisme), Protéine ADAMTS13, Protéines ADAM (métabolisme).
- MESH :
- effets indésirables : Dispositifs d'assistance circulatoire.
- métabolisme : Facteur de von Willebrand, Maladies de von Willebrand, Plaquettes, Protéines ADAM.
- étiologie : Maladies de von Willebrand.
- Adolescent, Adulte, Adulte d'âge moyen, Femelle, Humains, Jeune adulte, Mâle, Protéine ADAMTS13.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : ADAM Proteins, von Willebrand Factor.
- chemical : ADAMTS13 Protein.
- adverse effects : Heart-Assist Devices.
- etiology : von Willebrand Diseases.
- metabolism : Blood Platelets, von Willebrand Diseases.
- Adolescent, Adult, Female, Humans, Male, Middle Aged, Young Adult.
Abstract
The high shear rates induced by left ventricular assist devices cause acquired von Willebrand disease (aVWD). We hypothesised that an ex vivo model could be established to study whether mechanical shear stress alone causes aVWD or whether this process depends also on the VWF cleavage protein ADAMTS-13 and on platelets.
DOI: 10.1016/j.thromres.2015.11.002
PubMed: 26616301
Affiliations:
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Vienna</wicri:regionArea><wicri:noRegion>Medical University of Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Quehenberger, Peter" sort="Quehenberger, Peter" uniqKey="Quehenberger P" first="Peter" last="Quehenberger">Peter Quehenberger</name><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine, Division of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Laboratory Medicine, Division of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna</wicri:regionArea><wicri:noRegion>Medical University of Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Schima, Heinrich" sort="Schima, Heinrich" uniqKey="Schima H" first="Heinrich" last="Schima">Heinrich Schima</name><affiliation wicri:level="1"><nlm:affiliation>Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Center for Medical Physics and Biomedical Engineering, Medical University of Vienna</wicri:regionArea><wicri:noRegion>Medical University of Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Stoiber, Martin" sort="Stoiber, Martin" uniqKey="Stoiber M" first="Martin" last="Stoiber">Martin Stoiber</name><affiliation wicri:level="1"><nlm:affiliation>Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Center for Medical Physics and Biomedical Engineering, Medical University of Vienna</wicri:regionArea><wicri:noRegion>Medical University of Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Knobl, Paul" sort="Knobl, Paul" uniqKey="Knobl P" first="Paul" last="Knöbl">Paul Knöbl</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine I, Division of Haematology and Haemostasis, Medical University of Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Internal Medicine I, Division of Haematology and Haemostasis, Medical University of Vienna</wicri:regionArea><wicri:noRegion>Medical University of Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Steinlechner, Barbara" sort="Steinlechner, Barbara" uniqKey="Steinlechner B" first="Barbara" last="Steinlechner">Barbara Steinlechner</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cardiothoracic and Vascular Anesthesia, Medical University of Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Cardiothoracic and Vascular Anesthesia, Medical University of Vienna</wicri:regionArea><wicri:noRegion>Medical University of Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Felli, Alessia" sort="Felli, Alessia" 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Electronic address: Bernd.Jilma@meduniwien.ac.at.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Clinical Pharmacology, Medical University of Vienna</wicri:regionArea><wicri:noRegion>Medical University of Vienna</wicri:noRegion></affiliation></author></analytic><series><title level="j">Thrombosis research</title><idno type="eISSN">1879-2472</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ADAM Proteins (metabolism)</term><term>ADAMTS13 Protein</term><term>Adolescent</term><term>Adult</term><term>Blood Platelets (metabolism)</term><term>Female</term><term>Heart-Assist Devices (adverse effects)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term><term>von Willebrand Diseases (etiology)</term><term>von Willebrand Diseases (metabolism)</term><term>von Willebrand Factor (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Dispositifs d'assistance circulatoire (effets indésirables)</term><term>Facteur de von Willebrand (métabolisme)</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Maladies de von Willebrand (métabolisme)</term><term>Maladies de von Willebrand (étiologie)</term><term>Mâle</term><term>Plaquettes (métabolisme)</term><term>Protéine ADAMTS13</term><term>Protéines ADAM (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>ADAM Proteins</term><term>von Willebrand Factor</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>ADAMTS13 Protein</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Heart-Assist Devices</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Dispositifs d'assistance circulatoire</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>von Willebrand Diseases</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Blood Platelets</term><term>von Willebrand Diseases</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de von Willebrand</term><term>Maladies de von Willebrand</term><term>Plaquettes</term><term>Protéines ADAM</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Maladies de von Willebrand</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Protéine ADAMTS13</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The high shear rates induced by left ventricular assist devices cause acquired von Willebrand disease (aVWD). We hypothesised that an ex vivo model could be established to study whether mechanical shear stress alone causes aVWD or whether this process depends also on the VWF cleavage protein ADAMTS-13 and on platelets.</div></front></TEI><affiliations><list><country><li>Autriche</li></country></list><tree><country name="Autriche"><noRegion><name sortKey="Jilma Stohlawetz, Petra" sort="Jilma Stohlawetz, Petra" uniqKey="Jilma Stohlawetz P" first="Petra" last="Jilma-Stohlawetz">Petra Jilma-Stohlawetz</name></noRegion><name sortKey="Felli, Alessia" sort="Felli, Alessia" uniqKey="Felli A" first="Alessia" last="Felli">Alessia Felli</name><name sortKey="Jilma, Bernd" sort="Jilma, Bernd" uniqKey="Jilma B" first="Bernd" last="Jilma">Bernd Jilma</name><name sortKey="Knobl, Paul" sort="Knobl, Paul" uniqKey="Knobl P" first="Paul" last="Knöbl">Paul Knöbl</name><name sortKey="Quehenberger, Peter" sort="Quehenberger, Peter" uniqKey="Quehenberger P" first="Peter" last="Quehenberger">Peter Quehenberger</name><name sortKey="Schima, Heinrich" sort="Schima, Heinrich" uniqKey="Schima H" first="Heinrich" last="Schima">Heinrich Schima</name><name sortKey="Steinlechner, Barbara" sort="Steinlechner, Barbara" uniqKey="Steinlechner B" first="Barbara" last="Steinlechner">Barbara Steinlechner</name><name sortKey="Stoiber, Martin" sort="Stoiber, Martin" uniqKey="Stoiber M" first="Martin" last="Stoiber">Martin Stoiber</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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